What is your prediction for the derby?
We took our camera around Manchester to ask both United and City fans how they thought tonight's tussle would pan out.
As you'll see in our free video, there were some varied responses...
Discuss the derby with fellow Reds on our message board at manutd.com/talkingreds.
After watching their opinions in our free video above, why not have your say on our message board at manutd.com/talkingreds?
And if you're coming to Manchester, even when there isn't a match on, be sure to look out for our cameras and have your views at the ready.