With John O'Shea and Gary Neville sustaining injuries in Wednesday's senior win over Portsmouth, Wes Brown's return to action with United's Reserves couldn't be timelier.
The England international, who completed an hour against Preston on Monday, will start Thursday's match against Newcastle with one eye on this weekend's first team clash with Tottenham at Old Trafford.
"Wes will play for the Reserves on Thursday night which will be his second game [since returning from injury]," Sir Alex said after Wednesday's 2-0 win over Pompey. "We'll give him one half and he could be involved on Saturday."
Brown is joined by Tomasz Kuszczak, Darron Gibson and Fabio, who were all members of the Reds' FA Cup semi-final squad, as Ole Gunnar Solskjaer and Warren Joyce look to secure second spot in the Barclays Premier Reserve League table.
Kuszczak keeps goal behind a defence of Brown, Richard Eckersley, Ritchie De Laet and Fabio, while Lee Martin will again act as a makeshift striker ahead of Danny Drinkwater, Gibson, Matty James, Corry Evans and Zoran Tosic.
Back from his loan with Hereford United, Febian Brandy is on a substitutes bench which also hosts Ben Amos, Oliver Gill, Magnus Eikrem and Cameron Stewart.
Thursday's match will be shown live on MUTV, with coverage beginning at 18:30 BST.