Recent recruit Alexander Buttner made his first appearance for the club at left-back while Jonny Evans, Darren Fletcher and Anders Lindegaard all played the full 90 minutes.
With Sir Alex Ferguson, Angelo Henriquez and Tom Cleverley amongst those in attendance, a goal arrived almost instantly, with around 70 seconds on the clock. Ryan Tunnicliffe won the ball in midfield to release Macheda and, when his shot was blocked by Jordan Archer, it rebounded back off the Italian and deflected into the net.
Joshua King's blistering pace and some wayward shooting were the main features of the rest of the first half with Nick Powell having a shot blocked and then unable to supply the finishing touch following a run by the electric King. Captain Scott Wootton beat Harry Kane to head a dangerous cross behind and Spurs had openings but Andros Townsend, Iago Falque and Kane provided disappointing attempts.
King skied his finish after being put in the clear by the impressive Macheda and Robbie Brady clubbed an equally wayward shot off target as the Reds went in for the break a goal to the good. Buttner had to make a goalline clearance to thwart Townsend at the start of the second period before Macheda extended the lead from the penalty spot.
Powell collected a pass from the Italian striker and was unceremoniously bundled over by Adam Smith, allowing Macheda to calmly slot in his second goal of the night. Archer denied Michael Keane but Lindegaard was called upon at the other end to show his class. The Dane made a truly astounding double save to frustrate Jonathan Obika