The Reds meet the Midlanders in the Barclays Premier Reserve League play-off after the teams won the North and South divisions respectively in convincing fashion.
It's a repeat of the 2010 final, which United won on penalties, as Villa have reached this stage in four of the past five seasons. In fact, the two clubs have dominated since the format of the Reserves league changed with five regional titles apiece.
The 7pm kick-off, which is live on MUTV, is not the final game of the campaign for Warren Joyce's charges, with the Manchester Senior Cup final to follow against Manchester City at the Etihad Stadium next week.
"The final is something we can go and enjoy," explained Joyce to Inside United. "We want to give a good account of ourselves and win it, but it's a one-off game and anything can happen.
"The most pleasing thing is the players' development over the campaign. There are two big games at the end of the season and hopefully we can get reasonable crowds."
Joyce is likely to keep faith with many of the youngsters who won the league, despite the return of several players from loan spells away from Old Trafford. Jesse Lingard could be a key figure and he told ManUtd.com: "It'll be a good experience. I've played at Old Trafford in the FA Youth Cup and you get used to the size of the pitch.
"It should be a good atmosphere at both games - against Villa and City."