The South Coast side had two wins and two draws at the start of the campaign but were defeated by Stoke in their last outing at this level. Highly-rated full back Luke Shaw could feature and former Celtic keeper Artur Boruc was in goal for the 1-0 defeat to the Potters.
Warren Joyce is without a number of players who are away on international duty, including the likes of Robbie Brady, Nick Powell and Marnick Vermijl.
Bebe is drafted in for his first Under-21 appearance while Joshua King leads the line despite being in Norway's plans for their World Cup qualifiers. With a number of defenders in the line-up, Tom Thorpe is an option to anchor the midfield while keeper Pierluigi Gollini makes his debut at this level.
The Reds remain unbeaten after a goalless draw at Sunderland last week but will aim to show more of a cutting edge in front of the home supporters at Altrincham's Moss Lane.
United (provisional team): Pierluigi Gollini; Scott Wootton, Michael Keane, Michele Fornasier, Tyler Blackett; Bebe, Tom Thorpe, Larnell Cole, Ryan Tunnicliffe, Jesse Lingard; Joshua King. Subs: Frederic Veseli, Joel Pereira, Sean McGinty, Reece James, Luke Hendrie.
The match is live on MUTV with kick-off at 19:00 BST.