The Dutchman blasted a stupendous volley past Brad Guzan following Wayne Rooney's exquisite pass to notch his second strike in the 11th minute. Although he went on to complete his second hat-trick since joining the club, there was no doubting which effort will emerge as a Goal of the Season contender.
When asked if it is his best goal for United, the centre-forward replied: "It's hard. Maybe if I look at everything - the occasion, the day and the importance of the goal, maybe it is my most important."
The volley will be shown again and again and everybody inside Old Trafford will be able to say they were present to witness such a magnificent strike.
"It was a great pass from Wayne," said van Persie. "He had to spot my run because I went in front of Ron Vlaar. It was a brilliant pass - absolutely straight into my path. I was counting my steps and it came exactly in front of me so it was a brilliant pass.
"The only thing I had to do was time it right, keep my body straight and level with the ball. I did and it went in which was very nice. So it was a big relief. You need to be a bit lucky with those goals as most of them go over or wide but, today, it didn't so I was very pleased with that."