Watched by Reds legend Paddy Crerand, former United winger Andrei Kanchelskis and Galimzyan Khusainov, captain of the Soviet national team in the 1966 World Cup, the Reds slipped to a 3-1 defeat against their Russian hosts.
The match took place at Spartak Moscow's training ground, and was watched by a crowd of roughly 500 spectators - including reporters from national TV, radio and newspapers.
Both sides exchanged gifts before the game, while each side's Man of the Match was handed an extra special prize. United star man Andrew Kilduff was presented with an authentic Russian hat and military belt, while Spartak's outstanding player received a trip to see a United match and a tour of Carrington.
Former United winger Kanchelskis was delighted with the event, and told reporters: "I am very happy that Spartak and Manchester United fans have such friendly relations with each other. It is very important that fans try to find out who is stronger on the football field, not in a street fight."