We put the following questions about Sunday's clash to United fans from near and afar:
Can the Reds take all three points against Chelsea?
Did you ever see Chelsea creeping back into the title race?
Who is Chelsea's biggest threat to United?
What is your score prediction?
Have your say online: manutd.com/talkingreds
MUTV's Laura Kane caught up with supporters on the forecourt at Old Trafford to get their views on the biggest league game of the season.
You can read more comments from supporters, and post your own, on our official message board at manutd.com/talkingreds.