Brian Deane scored the very first goal in the new league and the Reds were defeated 2-1 at Bramall Lane despite Mark Hughes getting on the scoresheet.
So our trivia question this week is extremely straightforward. Name the Reds' starting line-up and two substitutes from that fixture on 15 August 1992.
Click here for our answers and look out for another poser next Thursday.
More United-based trivia questions: Goalkeepers meeting the Reds | Oldest scorers in Premier League | Internationals at Old Trafford | Old Trafford penalties | England's seven Reds | Alan Hardaker Trophy winners | Scored against United | United stars at European Championship | Goals for England | The name game | Non-appearance at finals