The England striker was the Reds' first Barclays Premier League goalscorer in both 2011 and 2009 and will be aiming to get off to another flier at Goodison Park.
Could you recall the last FIVE players, aside from Rooney, to score the opening goal of United's league campaign?
The answers are provided in the black box to the right.
Look out for another question next Thursday.
Previous United-based trivia questions: Old Trafford penalties | England's seven Reds | Alan Hardaker Trophy winners | Scored against United | United stars at European Championship | Goals for England | The name game
2011: Wayne Rooney
2010: Dimitar Berbatov
2009: Wayne Rooney
2008: Darren Fletcher
2007: Paul Scholes
2006: Louis Saha
2005: Ruud van Nistelrooy