Supporters have taken to Talking Reds to offer their views on the XI with a wealth of options available to the manager. Get in touch via our forum or by using the hashtag #manutdtactics on Twitter and we will post a selection of the best comments here. We would like your thoughts on the side, formation and any specific tactics.
G_babse: Personally, I think it will be the same team that played at the Bernabeu. I think a 4-5-1 formation with Rooney and Welbeck defending and attacking on the wings will be good enough to take us through.
David D'Genius: Cleverley will move the ball faster on the attack and will link up better with the front line. Vidic should be back. We'll sure miss Phil Jones as we need someone in there who will run for 90 minutes, covering space without losing concentration.
Sunera Kulasekera: I hope we go 4-4-2 with Valencia and Nani/Young on either wings and Carrick and Cleverley in the midfield. But Sir Alex will play a 4-2-3-1 with no wingers and Carrick and Cleverley in midfield and Kagawa, Valencia/Nani, Rooney, RvP playing up front.
Maci: Antonio Valencia to start tonight! His pace, aggression and his strength will be needed alongside Rafael to stop Ronaldo.
MUF Kosova: I think the wings with be decisive in this match! We will defend strongly with Carrick and Cleverley defensive midfielders.
Twum Barimah Afoakwa: Evans in for Vidic because of his pace, Anderson in for injured Jones because he has the big- match temperament and Nani for his flair.