Louis van Gaal's first competitive match in charge of the Reds is at home to Swansea, and the three teams promoted from the Championship - Leicester City, Burnley and Queen's Park Rangers - are also lined up within the opening weeks of 2014/15.
Watch what fans outside Old Trafford had to say about the new season schedule in our video above, while over on @ManUtd, the club's official Twitter count, fans turned #mufcfixtures into a worldwide trending topic. Here's our pick of the best tweets:
@Juan_United_Fan No game is a given in the Premier League. But I'm sure our new boss will be happy with that start. Good luck van Gaal!
@Daniel_R_Hughes So we have Liverpool, Man City, Chelsea, Everton and Arsenal in the last nine games of the season. No sweat.
@RichardJude October/November and March/April are where the #MUFCfixtures throw up tough runs, but otherwise they're ideal.
@mtaDavadilla Top of the table after the first five games.
@loveMCR Great start - can't wait to get back on the away game train. #mufcawaydays