Both substitutes had a quick impact on play. Anderson's free-kick was well fielded by substitute goalkeeper Lars Hirschfeld, before neat approach play from Kagawa culminated in Nani blasting over the bar. The hosts retained a threat, however, and Chuma Anene came close twice in quick succession; firstly as his shot was deflected wide by Michael Carrick, then secondly as his header was dramatically cleared off the line by Rooney.
It was always United who looked most likely to break the deadlock, however, and Valencia's drilled cross-shot came agonisingly close to putting the visitors ahead. That miss heralded another trio of changes, with Rooney, Scholes and Young making way for Chicharito, Jesse Lingard and Nick Powell. The little Mexican striker was inches away from turning in a late winner when Nani and Kagawa combined superbly, but Chicharito was just unable to reach the Japanese playmaker's fizzed cross.
With little more than a minute remaining, the same outcome met another slick United move. This time, after Kagawa had released Valencia, the Ecuadorian's cross was stabbed towards goal by Chicharito, only for Hirschfeld to trap the ball with his body.
He was beaten in injury-time as Anderson strode forward and unleashed a curling effort, but the Brazilian's shot also cleared the crossbar by a matter of millimetres, ensuring a goalless outcome.
Nevertheless, invaluable game-time for United's senior stars, including the all-important presence of skipper Vidic, constituted a largely positive afternoon's work on a tour which now heads to Gothenburg for a high-profile summit with Barcelona.
United: Lindegaard; Valencia, Vidic (Anderson 61), Ferdinand, M Keane; Nani, Carrick, Scholes (Powell 75), Young (Lingard 75); Rooney