What is it about this fixture that serves up so much excitement? Eleven years to the day after United came from 3-0 behind to win 5-3 at White Hart Lane, Sir Alex's men were at it again.
This time, the comeback never reached its completion. In fact, barring the first two minutes of the game, the Reds were never even on level terms. But 180 seconds at the beginning of the second half – three minutes of madness that produced three goals – was worth the price of admission alone and epitomised the drama that has long characterised clashes between these sides.
Tottenham, of course, have always played their part in the excitement and on Saturday afternoon Andre Villas Boas' side, a team laden with pace and purpose, were rewarded with a victory that finally ended a 26-game winless streak at Old Trafford.
It's a run that stretched back to 1989, a time when Alex Ferguson had yet to win a trophy with United and before both of this game's right backs – Rafael da Silva and Kyle Walker – were even born.
The wheels of Tottenham's historic victory were set in motion after just two minutes, when the vicitors took the lead before Reds goalkeeper Anders Linegaard had touched the ball. The Dane was understandably furious, as Spurs left-back Jan Vertonghen was allowed to waltz into the penalty area almost unchallenged before stroking an effort goalwards that deflected off Evans and into the net.
It was the worst possible start for Sir Alex's men, and the fifth time in six league games this season the Reds have conceded first.
Worryingly, Aaron Lennon was afforded similar space to run at United's defence just six minutes later. This time, however, a last-ditch tackle