Date, time and coverage: Monday 26 August (kick-off: 20:00 BST). The match is live in the UK on Sky Sports and you can follow it via ManUtd.com’s live blog and MUTV Online's radio commentary.
Form guide: United began the new Barclays Premier League season by recording a hugely impressive 4-1 win over Swansea City last weekend, a match that had been earmarked as a potential banana skin for the champions. That triumph was preceded by a 2-0 victory over Wigan Athletic in the FA Community Shield at Wembley. Chelsea have also got off to an encouraging start, beating Hull City 2-0 at Stamford Bridge before sealing another home win over Aston Villa on Wednesday. The latter was rearranged for midweek because of the Blues ' involvement in the UEFA Super Cup.
Ins and outs: Rafael's suspension, which was earned via a sending off against Chelsea last term, is now over but the Brazilian remains unavailable through injury. Wayne Rooney could start following his cameo in Wales last time out, although Ashley Young (ankle), Nani (groin) and Chicharito (hamstring) are all likely to miss out. Meanwhile, David Luiz is a doubt for Chelsea, who are also without Thomas Kalas.
Betting: United’s official partner bwin have the Reds priced as favourites at 2.30 and Chelsea at 3.00, with the draw at 3.30. As always, more tempting odds can be found in match predictions – you can get 9.75 on the Reds winning 1-0 or a very generous 23.00 on 3-2.