Date, time and coverage: Wednesday 4 December, 19:45 GMT. The match will not be televised live in the UK, but you can follow it via ManUtd.com’s live blog and MUTV Online’s radio commentary and then watch the game in full on MUTV.
Form guide: A 2-2 draw with Tottenham stretched United’s unbeaten run to 12 matches in all competitions, adding to the theory that the champions are getting into gear just ahead of the important Christmas period. Specifically, Wayne Rooney is enjoying a white hot run of form, having scored a brace at White Hart Lane to take his tally for the season to 10. Meanwhile, Everton are without defeat in six matches and head to Old Trafford on the back of a thumping 4-0 win over Stoke City at Goodison Park, a triumph that lifted the Toffees up to fifth place in the Barclays Premier League.
Ins and outs: Danny Welbeck returned from a two-month absence to face Spurs but left the action after 70 minutes with cramp to cast doubt over his involvement against Everton. Robin van Persie could take his place after missing the last three matches, although Phil Jones is unavailable through suspension. Everton are expected to be without Leighton Baines, who is struggling with an ankle injury. Arouna Kone and ex-Reds midfielder Darron Gibson are also set to miss out with knee problems.
Betting: Predictably, bwin have priced United as favourites at odds of 1.70, with Everton at 5.00 and the draw 3.60. If you’re looking for more value, why not back Marouane Fellaini to score first - against his former club - at 11.00?
The manager: Roberto Martinez gained plenty of admirers during his time at Wigan Athletic and despite overseeing the Latics’ relegation to the Championship, the Spaniard was a man in demand after announcing his resignation in May. So much so, he was back in work just seven days later, taking