Date, time and coverage: Wednesday 27 November, 19:45 GMT. The match will be shown live on Sky Sports in the UK. Follow ManUtd.com's live blog and MUTV Online's exclusive radio commentary.
Form guide: Unbeaten in Europe so far this season, the Reds will qualify for the knockout stage of the Champions League with victory in Leverkusen. Currently second in the Bundesliga, Leverkusen's only defeat in Europe this season came on matchday one at Old Trafford. Stefan Kiessling's goal was enough to hand the German side victory away to Hertha Berlin on Saturday, and since that 4-2 loss at OT, Leverkusen have tasted defeat just once in 12 outings. They are also unbeaten at the BayArena in all competitions since losing to Bayern Munich at home last March.
Ins and outs: Marouane Fellaini is suspended following his red card in the 0-0 draw with Real Sociedad, and David Moyes will be without Robin van Persie (groin), Nemanja Vidic (concussion) and Michael Carrick (Achilles), all of whom did not travel to Germany. Vidic trained on Tuesday but is being given additional time to recover from concussion. Rafael, Phil Jones and Shinji Kagawa, who all missed the 2-2 draw with Cardiff, are available. Leverkusen are without Sidney Sam, scorer of eight goals so far this season, due to a thigh injury picked up against Hertha. Defender Sebastian Boenisch could return having rested a tendon complaint. Roberto Hilbert (knee) and Stefan Reinartz (ankle) both miss out.
Betting: There's not a lot to choose between the two sides according to bwin, our official betting partner. United are 2.90 to win, while you can get