Last meeting: The Reds kicked off our latest Champions League campaign with a 4-2 win back in September. Simon Rolfes cancelled out Wayne Rooney's opener, but after Robin van Persie had restored the lead, another for Rooney and one from Antonio Valencia helped United towards a comfortable three points.
Did you know? Wayne Rooney became the highest-scoring British player in the history of the Champions League, overtaking Ryan Giggs, when he grabbed his second goal against Leverkusen at Old Trafford in September.
The manager: Former Liverpool defender Sami Hyypia, in his first season in sole charge of Leverkusen, has guided the German club to second place in the Bundesliga after 13 games.
Star man: Striker Stefan Kiessling may have missed out at OT in September, but the 29-year-old has found the net 12 times this season, including two in the 4-0 win over Shakhtar Donetsk on matchday three. Kiessling is approaching 150 goals in nine years with Leverkusen, but he recently stated he would not play for his country while Joachim Low remains as coach of the German national side, having won won the last of his six caps in 2010.
Quote/unquote: "We need to pick up points and it would be nice if we could finish the job this week with a win. If we go there and put in a good team performance I'm sure we can come away with the points." - Rio Ferdinand.
Whistle-blower: Svein Oddvar Moen, 34, from Norway will take charge in the BayArena.
Rivals watch: Real Sociedad, currently propping up Group A, need to beat Shakhtar away in the Donbass Arena and hope for a United win to retain any hopes of advancing to the last 16.