Date, time and coverage: Saturday 19 October, 15:00 GMT. No live TV coverage in the UK. Follow the action live via ManUtd.com's rolling blog and MUTV Online's radio commentary.
Form guide: After returning to winning ways against Sunderland at the Stadium of Light courtesy of two Adnan Januzaj strikes, United's players spoke of a desire to put a run of results together. However, with Southampton boasting the second best defensive record in Europe, David Moyes' men face a tough task to make it two wins on the bounce.
Ins and outs: Fortunately, United are in reasonably rude health at the moment. There are, however, doubts surrounding the availability of Rio Ferdinand, Rafael and Tom Cleverley, who have all picked up slight knocks in recent weeks. Former Celtic stopper Artur Boruc and promising left-back Luke Shaw may not feature for Southampton, but otherwise the Saints have few injury concerns.
Betting: Despite the Saints' impressive form, United's official partner bwin have the Reds priced as favourites at 1.5, Southampton at 6.5 and the draw at 4.0. Fresh from firing England to the World Cup finals in midweek, why not back Wayne Rooney to score first on 5.00?
Last meeting: In January, United faced a stern test against Mauricio Pochettino's side. The visitors scored early before Wayne Rooney's first-half brace put the Reds 2-1 up at the break. Southampton put United under intense pressure after the break as the south coast side attempted to forge a way back into the match. It wasn't to be, however, as the table-toppers edged closer to a 20th league crown.