Date, time and coverage: Wednesday 2 October at 19:45 BST. Watch live on Sky Sports, or follow via ManUtd.com’s live blog and MUTV Online's radio commentary.
Form guide: United will be determined to bounce back from Saturday's Barclays Premier League defeat to West Brom by building on last month's 4-2 win over Bayer Leverkusen in the first UEFA Champions League fixture. Similarly, Shakhtar Donetsk kicked off their European campaign with an impressive 2-0 victory at Real Sociedad - and last Saturday they came back from two down to earn a 2-2 draw with local rivals Metallurg Donetsk in the Ukrainian Premier League.
Ins and outs: Robin van Persie could start for the Reds after the Dutchman returned from injury as a substitute at the weekend. Nemanja Vidic and Patrice Evra may also feature, having been rested completely against the Baggies, while Marouane Fellaini will be hoping for his first United appearance on foreign soil. Shakhtar will be without Brazilian striker Wellington Nem, who was left out of their Champions League squad after picking up a knee injury following his summer move from Fluminense.
Betting: United’s official partner bwin have priced United at 2.85 to win, while Shakhtar are 2.40 and the draw is 3.30. A 2-0 win for the Reds is 14.00, while a flutter on Wayne Rooney scoring two or more is a tempting 17.00.
Last meeting: United have never played Shakhtar Donetsk, although the Reds are unbeaten against Ukranian opposition. In four meetings with Dynamo Kiev, the Reds have won three matches and drawn one.