Kiev, the Reds have won three matches and drawn one.
The manager: Mircea Lucescu is Shakhtar's longest-serving coach, having been in charge since May 2004. During that time, he has guided the Ukrainian club to seven league titles as well as the UEFA Cup in 2009. As a player, the now 68-year-old was capped 70 times by his native Romania.
Star man: Shakhtar's squad features a bevy of Brazilian players but midfielder Alex Teixeira could be the one to watch, having bagged both goals in his side's 2-0 Matchday One win away to Real Sociedad.
Sub-plot: Shakhtar have never lost to English opposition on home soil in the Champions League. However Wayne Rooney will happily recall his previous visit to the Donbass Arena, where he scored the only goal in England's Euro 2012 win over Ukraine that knocked the host nation out at the first hurdle.
Did you know? Mircea Lucescu quit as Inter Milan manager a few days after United knocked the Italians out of the Champions League at the quarter-final stage in 1999.
Whistle-blower: Pavel Kralovec will be the man in the middle on Wednesday. The Czech has been a FIFA referee since 2005 but is yet to take charge of a United match. He did, however, officiate Manchester City's 1-1 draw with Borussia Dortmund last season.
Quote/unquote: "I think we need to go there with a strong team. Going to Ukraine is tough because