Date, time and coverage: Sunday 22 September (Kick off: 16:00 BST). The match is live in the UK on Sky Sports and you can follow it via ManUtd.com’s live blog and MUTV Online's radio commentary.
Form guide: United go to the Etihad Stadium on the back of two wins in a week, with a solid 2-0 triumph over Crystal Palace followed by Tuesday's 4-2 victory over Bayer Leverkusen. A much-altered Manchester City side failed to impress in a listless 0-0 draw with Stoke last Saturday, but they comfortably despatched Viktoria Plzen in the Champions League, 3-0, on Tuesday.
Ins and outs: David Moyes hinted at minimal changes in his press conference on Friday, when he said "the recovery time from Tuesday to Sunday isn't difficult." No update was provided on recent absentees Rafael, Phil Jones and Danny Welbeck. City looked shaky in defence without Vincent Kompany, but the Blues captain returned from a groin problem in midweek. Spanish trickster David Silva has been rated as a major doubt for the derby after picking up a thigh muscle injury on international duty.
Betting: United’s official partner bwin have priced United at 2.10 to win and City at 3.30 while the draw is 3.40. Marouane Fellaini as the game's first scorer is priced at 13.00, while a repeat of last year's 3-2 win for United is a tempting 31.00.
Last meeting: The Blues came from behind to win 2-1 at OT in April, but Reds fans will prefer to recall last December's trip to M11. Wayne Rooney put United 2-0 up at half-time, but after City drew level Robin Van Persie's stoppage-time free-kick sealed yet another dramatic last-gasp derby win.