to the knock-out phase of the Champions League, but in between those two jobs the Chilean lasted just one season in charge of Real Madrid, despite having Cristiano Ronaldo in his ranks following the Portuguese's departure from Old Trafford.
Star man: Sergio Aguero looks to have assumed the mantle as City's main man up front now that fellow Argentina striker Carlos Tevez has left the club. Behind him, Yaya Toure is always a threat while on the flanks the pace of recent arrival Jesus Navas could test United's full backs.
Sub-plot: David Moyes had a good record at the Etihad Stadium whilst in charge at Everton - he won five of his 10 games in charge of the Toffees there.
Did you know? Wayne Rooney has scored eight times at the Etihad Stadium - six for United, and two in England's 6-1 win over Iceland there in 2004.
Referee: South Yorkshire official Howard Webb has yet to show a red card this season, but he sent off Reds right-back Rafael when he last took charge of a United fixture - the 0-1 home defeat to Chelsea in May.
Quote/unquote: "I’ve experienced derby games in Glasgow and on Merseyside. But every derby in every big city is important to whichever team you support and I understand how important it is for the Manchester United fans." - David Moyes
Rivals watch: League leaders Liverpool host Southampton on Saturday at 15:00 BST, while Chelsea are at home to Fulham for a West London derby at 17:30. Arsenal will have just finished their match at home to Stoke when United face City on Sunday afternoon. Spurs also kick off at 16:00, away to Cardiff.