Last season the Reds went to the Etihad and clinched one of United's best wins of the season, claiming a dramatic, late 3-2 win to hush our noisy neighbours. But it's all change this season with new managers at the helm, new players and a new challenge to finish top of the league.
For such a big encounter, our Matchday Podcast is your perfect on-the-go guide to the game, and to preview the match ManUtd.com's journalists Adam Marshall and James Tuck are in the studio with our host, MUTV's Mark Sullivan.
We also canvass the opinions of United legends Arthur Albiston, Paddy Crerand and Lou Macari. They discuss what they think will be the key battle areas on Sunday and how they think United and City will fare.
Last but not least, stats geek Nick Coppack slips on his bifocals and anorak and guides us through all the key facts and figures ahead of Sunday's showdown.
Listen to the podcast in the player above, or download the mp3 here.