Date, time and coverage: Wednesday 22 January, 19:45 GMT. Live TV coverage in the UK on Sky Sports. Follow the action live via ManUtd.com's rolling blog and MUTV Online's radio commentary. Match highlights will be on MUTV Online from 24 hours after full-time.
Form guide: Defeat to Chelsea on Sunday meant a fourth defeat in five outings for Manchester United in 2014, while the visitors are on a four-match unbeaten run. The Black Cats' latest result showed character – after trailing 0-2 at home to Southampton on Saturday, they turned it around to claim a point with a 2-2 draw.
Ins and outs: United will be without skipper Nemanja Vidic, who begins a three-match ban for the straight red card he received at Stamford Bridge. Marouane Fellaini is edging back towards full fitness following wrist surgery and a back injury, but the Belgian is still some time away from availability. Robin van Persie and Wayne Rooney missed the trip to Chelsea due to their ongoing thigh and groin issues but David Moyes said on Sunday that he hoped the pair were not far away from full fitness. Sunderland have brought in defender Santiago Vergini on loan this week, but it remains to be seen if the Argentinian will make the squad for Wednesday.
Last meeting: Sunderland claimed the first-leg spoils with a 2-1 win, which came courtesy of an own goal from Ryan Giggs and a penalty from on-loan Liverpool striker Fabio Borini. It was a cruel stroke of luck for Giggs, who struck the crossbar and was flagged offside when Adnan Januzaj 'scored' before he inadvertently put the home side ahead. Vidic's header levelled the match early in the second half, but Borini restored Sunderland's lead from the spot after Tom Cleverley was controversially adjudged to have fouled Adam Johnson