Date, time and coverage: Wednesday 19 March, 19:45 GMT. The match will be shown live in the UK on Sky Sports. You can also follow it live via ManUtd.com's rolling blog and MUTV Online's exclusive radio commentary. Highlights will be available from 23:00.
Form guide: Two Steven Gerrard penalties and a Luis Suarez strike saw United lose 3-0 to Liverpool on Sunday, a result that leaves the Reds seventh in the Barclays Premier League table and some distance away from the top four. But with a make-or-break Champions League tie to contend with, there is no time for sorrow and David Moyes must find a way to galvanise his players ahead of facing Olympiacos at Old Trafford. The Greeks hold a 2-0 lead from the first leg in Piraeus, which means they will qualify for the last eight if they avoid defeat by three clear goals. Michel’s men head to the Theatre of Dreams on a high, too, after sealing their 41st league title (with five games to spare) via a 2-0 win over Panthrakikos FC on Saturday.
Ins and outs: Juan Mata is ineligible to play, having already featured in this season’s competition with Chelsea, and will therefore take his seat in the stands. Shinji Kagawa might be recalled, while Antonio Valencia and Ashley Young could both return after sitting out Sunday’s match. Chris Smalling remains a doubt with a hamstring injury but Nani could make his first appearance since 7 December. Meanwhile, Olympiacos are likely to be without experienced campaigner Javier Saviola, the former Real Madrid and Barcelona striker, who is struggling for match fitness.
Betting: Official betting partners bwin have United priced at odds of 2.60 to qualify and Olympiacos as favourites at 1.46. You can also back the Reds to win the second leg 3-0, the result that is needed to ensure qualification, at 9.75.