Date, time and coverage: Saturday 22 March, 17.30 GMT. The match will be shown live on Sky Sports in the UK. Follow ManUtd.com's live blog and MUTV Online's exclusive radio commentary.
Form guide: United will want to put right Sunday’s dismal defeat at home to Liverpool by getting back to winning ways in the Barclays Premier League at the Boleyn Ground. The midweek triumph over Olympiacos will have channelled renewed confidence into the Reds' ranks, which could be crucial, as David Moyes aims to end the season in positive fashion. West Ham are without a win in two games, however their excellent February form, which featured four wins out of four, ensures the Hammers currently sit in 12th place – six points clear of the drop zone.
Ins and outs: Moyes’ squad remains in reasonably rude health despite recent defensive injuries to Jonny Evans and Chris Smalling while Nemanja Vidic is suspended. Nani could be in line for a return to the squad after a long lay-off but the injury Robin van Persie picked up towards the end of Wednesday's game rules him out. Similarly, Marco Borriello and Joey O’Brien serve as West Ham’s only absentees meaning that Sam Allardyce has the luxury of an almost fully-fit squad to contend with as his side welcome the champions to Upton Park.
Betting: United’s official betting partner bwin have the Reds priced at 1.80 favourites ahead of Saturday’s match with West Ham in at 4.20 and 3.60 for the draw.
Last meeting: Back in December, United well and truly burst the Hammers’ bubbles as goals from Danny Welbeck, Adnan Januzaj and a stunning strike from Ashley Young gave the Reds a 3-1 win at Old Trafford.
Did you know?: United have won nine of the last 10 home and away league meetings with West Ham.