Europe have ended up with a nine-point cushion in their last two successes and it’s 30/1 for the holders to triumph by an 18½-9½ scoreline again.
It's 10/1 for either Ian Poulter or Paul Casey to gain the singles result that wins the trophy. Poulter and Casey are both 3/1 to win their singles matches.
World number two Phil Mickelson is 11/2 joint favourite with Jim Furyk to be the USA's top scorer.
Play Blackjack online with Betfred during the Ryder Cup and you'll win a cash prize if you finish in the top 20.
£1,000 will be added to the prize pool every time a golfer bags a hole in one at the Ryder Cup on Friday 19, Saturday 20 or Sunday 21 September.
See manutd.betfred.com/casino for full details of Betfred's Blackjack promotion.