As United and Barcelona take to the field on Wednesday evening, the Stadio Olimpico's Curva Nord will transform into a tribute to Sir Matt Busby.
United supporters at the game will be salute one of football's greatest manager, the day after the 100th anniversary of his birth, with a special mosaic ahead of kick-off.
The giant display, organised by the club in association with the Stretford End Flags supporters' group, will spell out 'For Sir Matt' next to a giant image of the legendary Scot.
The mosaic follows previous projects between United and SEF, including the mosaics which preceded last year's semi-final win over Barcelona, the final in Moscow, Ole Gunnar Solskjaer's testimonial and this season's home victory over Arsenal.
Stretford End Flags is a donation-powered organisation devoted to the colourful and buoyant support of United, at home and abroad. For more details, visit www.stretfordendflags.com.