A replica of the programme from the inaugural match - against Liverpool on 19 February 1910 - will be distributed to every fan passing through the turnstiles.
One hundred free tickets have been issued to local residents through the Gorse Hill Partnership, a link-up between United and Trafford Borough Council.
Banners in the North Stand tunnel tell the story of OT's development, while the artwork of local school children is on display in the Family Stand concourse.
A special 100 Years of Old Trafford magazine will be on sale around the ground.
Club secretary Ken Ramsden says, "The club is immensely proud to have been at Old Trafford for 100 years. To celebrate the centenary with our supporters is very important."