And now, for the first time, Thomas Cook Sport is offering fans the chance to book chartered return train travel for the match from London Euston.
The service, which stops only at Watford Junction and Milton Keynes en route to Manchester Piccadilly, is available from just £45 per person. The trains are chartered exclusively by Thomas Cook Sport and available only to United fans travelling to the match.
Sir Alex Ferguson has described the meeting with Real Madrid, which will reunite Cristiano Ronaldo with Old Trafford for the first time since his departure in 2009, as "the tie of the round".
So don't miss out and book your travel now. Your carriage awaits!
Approximate travel times:
Depart London Euston 14:51
Arrive Manchester Piccadilly 17:30
Depart Manchester Piccadilly 23:09
Arrive London Euston 02:31