Club partner Chevrolet has arranged for a panoramic picture to be taken at 20:05 BST, five minutes after kick-off, and fans in attendance are encouraged to make a show of colour and noise to help the camera capture the passion of the Old Trafford faithful, as they help drive the team on towards hopefully winning a 20th league title.
The first such Chevrolet Fan Pic was taken at United's 2-1 victory over Liverpool in January, and it was so successful that they want to make it a more regular feature at Old Trafford. You can still view the Liverpool match photo at www.manutd.com/360fanpic.
On Monday, the picture will be taken from a location near the players' tunnel in the south-west quadrant. The finished photo will be online within 24 hours of the final whistle, enabling supporters to scour the stands and tag themselves while hunting for friends and family members in the photo. Fans who can't make it to the game can still get involved by viewing the picture, adding photographs to the virtual stadium and taking part in a number of games, all at www.manutd.com/360fanpic.