Reds legend Paddy Crerand anticipates selection changes for both teams at the Bridge...
When you're involved with United, the big games really do come thick and fast at this stage of the season. Hot on the heels of a semi-final clash with Barcelona, you're looking to sew the title up against Chelsea at Stamford Bridge.
It will be interesting to see the teams that Sir Alex and Avram Grant pick on Saturday because the Champions League semi-finals could well affect their decisions.
I'm sure the United side will be different to the one that earned a workmanlike 0-0 draw in Barcelona - we'll need to freshen things up. Chelsea's semi final opponents Liverpool haven’t got anything to play for in the league, so they will rest players at Birmingham.
That means Grant has a decision to make. He will want to be at full strength to face Liverpool on Wednesday, but first he’s got to pick a side to beat United and keep their title hopes alive. Can he afford to rest players?
I would imagine if you’re a season ticket holder at Old Trafford, you might settle for a draw against Chelsea, so victory against West Ham can secure the league title on home turf. So a draw would be a great result but defeat... that cannot be an option for United as it would throw everything wide open.
Chelsea have not lost at home since February 2004. It's an unbelievable record, but that only fires United up even more. Remember how we stopped Arsenal from reaching 50 matches unbeaten?