Chelsea have been our main title rivals in the 2000s and have provided some ding-dong battles. Ahead of the decade's final meeting (barring a Carling Cup tie), we recall some of this fixture's most memorable moments (click the main image for full gallery)...
United 3-2 Chelsea 24 April 2000
After the 5-0 hammering at Stamford Bridge earlier in the season, Dwight Yorke's double and Ole Gunnar Solskjaer's strike gave the newly-crowned champions (again) sweet revenge in the first meeting of the 2000s.
United 3-3 Chelsea 23 September 2000
Rarely a goal-fest these days, this was the highest-scoring of the decade. Jimmy Floyd Hasselbaink gave Chelsea an early lead, United responded to go 3-1 up with goals from Scholes, Sheringham and Beckham. But then it went to pot as Tore Andre Flo bagged a levelling brace to earn a point.
Chelsea 0-3 United 20 April 2002
The Reds exacted fitting revenge for defeat by the same scoreline at OT in December. Scholes' 30-yard rocket, van Nistelrooy's tap in and Solskjaer's late finish sealed it.
Chelsea 2-2 United 23 August 2002
This Friday night clash was a real edge-of-the-seat thriller at the Bridge. It was gritty stuff, too, as United twice came from a goal down through goals from Beckham and Giggs to earn a valuable early-season away point.
United 1-0 Chelsea 17 December 2002
The Reds were in fine form at the time - and so was Diego Forlan! This dramatic late League Cup quarter-final winner in the 80th minute - after cheekily nutmegging Carlo Cudicini - was his seventh goal in nine starts.
United 2-1 Chelsea 18 January 2003
Chelsea took the lead through Eidur Gudjohnsen after 30 minutes, but Scholes promptly replied, leaving the rest for Forlan again. With seconds remaining Forlan's explosive finish clinched a memorable victory and only served to enhance his cult status.
United 1-0 Chelsea 06 November 2005
Following a horrid week, consisting of a 4-1 defeat to Middlesbrough and 1-0 loss to Lille, beating Jose Mourinho's men seemed out of the question. But United dug deep for a rousing display,