Chelsea have been our main title rivals in the 2000s and have provided some ding-dong battles. Ahead of the decade's final meeting (barring a Carling Cup tie), we recall some of this fixture's most memorable moments (click the main image for full gallery)...
United 3-2 Chelsea 24 April 2000
After the 5-0 hammering at Stamford Bridge earlier in the season, Dwight Yorke's double and Ole Gunnar Solskjaer's strike gave the newly-crowned champions (again) sweet revenge in the first meeting of the 2000s.
United 3-3 Chelsea 23 September 2000
Rarely a goal-fest these days, this was the highest-scoring of the decade. Jimmy Floyd Hasselbaink gave Chelsea an early lead, United responded to go 3-1 up with goals from Scholes, Sheringham and Beckham. But then it went to pot as Tore Andre Flo bagged a levelling brace to earn a point.
Chelsea 0-3 United 20 April 2002
The Reds exacted fitting revenge for defeat by the same scoreline at OT in December. Scholes' 30-yard rocket, van Nistelrooy's tap in and Solskjaer's late finish sealed it.
Chelsea 2-2 United 23 August 2002
This Friday night clash was a real edge-of-the-seat thriller at the Bridge. It was gritty stuff, too, as United twice came from a goal down through goals from Beckham and Giggs to earn a valuable early-season away point.
United 1-0 Chelsea 17 December 2002
The Reds were in fine form at the time - and so was Diego Forlan! This dramatic late League Cup quarter-final winner