The Reds have enjoyed plenty of ding-dong battles at Eastlands and Maine Road in the Premier League era, and the last three clashes have been settled by the odd goal.
City will be desperate to put another nail in United's title coffin by exacting revenge for the Carling Cup semi-final defeat and September's epic at Old Trafford.
But Sir Alex's men have only conceded once in the last three visits to City and will be determined to complete the league double and stay alive in the championship race.
If Wayne Rooney is passed fit, he'll be aiming to add to the two decisive league goals he's scored at Eastlands – last season and in 2004/05.
Click the main image above to view our photo gallery of City v United encounters.