United visit Blackpool's Bloomfield Road home for the first time in 36 years this weekend.
Our video shows goals from five other Premier League games at venues the Reds were visiting for the first time, or the first time in decades...
Swindon 2-2 United, 19/03/1994
Bradford 0-4 United, 25/03/2000
Wigan 1-2 United, 06/03/2006
Reading 1-1 United, 23/09/2006
Hull 0-1 United, 24/05/2009
United have often faced a stern test on visits to unfamiliar grounds...
Bradford ('00): The Bantams were brushed aside as they welcomed Sir Alex's men to Valley Parade for the first time since 1982, Paul Scholes volleying the pick of the goals.
Wigan ('06): Wigan gave it everything in their first ever meeting with United, but Cristiano Ronaldo and a last-gasp Pascal Chimbonda own goal rescued the Reds.
Reading ('06): After Kevin Doyle's penalty put Reading ahead, United again had Ronaldo to thank the following season for a point in our first ever league meeting with the Royals.
Hull ('09): United visited Hull for the first time since 1987 on the final day of the 08/09 season. Already champions, Darron Gibson's brilliant long-range strike secured the win.