Things started well enough when he came on as a substitute in the Gunners' 2004 Community Shield win, helping his new team to a 3-1 victory with all the goals coming in the second half. After all he picked up in a Carling Cup defeat at Old Trafford was a yellow card, the striker again left the bench to convert a penalty in the FA Cup final shoot-out success against the Reds at the end of that first season.
Following a 2-0 defeat at Old Trafford in 2006, he scored in two of the next three games against the Reds including the Champions League semi-final second leg in 2009. A goalless draw at the Theatre of Dreams led to United clinching the title later that campaign and three defeats followed in all competitions before he was part of the Arsenal side that won 1-0 in 2011 thanks to an Aaron Ramsey goal.
Of course, he netted in both games against United last term - in the 8-2 thumping, when also having a penalty saved by David De Gea, and the 2-1 triumph for Sir Alex's team at the Emirates Stadium in January.
Check out MUTV's exclusive video featuring van Persie in action against the Reds.