Sir Alex has revealed the team news ahead of Wednesday's opening DHL tour game against AmaZulu.
Speaking after arriving in Durban, the boss revealed there will be a mix of youth and experience on show with Robbie Brady handed the chance to impress at left-back.
The winger has played there for the Reserves and is set to start, with Jesse Lingard operating further up the pitch and Shinji Kagawa making his debut.
"The priority is to get the experienced players fit but young players will play in each game. It's likely that Kagawa will start with Chicharito.
"Michael Carrick, Rio Ferdinand and Paul Scholes will play. So too Anders Lindegaard, Lingard and Brady at left-back. Antonio Valencia will play.
"Young Robbie Brady will be at left-back. He's actually an outside-left but we believe there's the possibility he'll develop into a left-back. He was on loan last year at Hull City and did very well. He'll certainly figure at left-back. I don't know how many substitutes will be allowed - we need to establish that - but I'm sure we can be flexible. It's important the young players get a chance to play on such a big occasion.
"Left-back is an area which we're paying attention to. Patrice, in the last five years has played an average of 45-50 games. It's phenomenal. I don't know if anybody else has achieved that. He's still a fit lad and has the same drive and ambition. He's a fighter.
"Fabio went to QPR, which was so important for the boy because he has enormous ability, but he needs to play. Because Evra, touch wood, is never injured, the opportunities haven't been there for the boy. He played a few games last season but it's not enough for a young boy of 21 years. He needed to continue with his progress. With Fabio at QPR for a year, we're just a little short in that