Wayne Rooney put through his own net before heading home an equaliser at the other end. Robin van Persie and Danny Welbeck netted either side of half-time to give United a 3-1 lead, but Michael Kightly gave the visitors hope with a low finish past De Gea after evading the attentions of three defenders. Rooney made sure of the victory soon after, though, with a close-range finish from a corner.
The 4-2 win keeps United four points behind leaders Chelsea, who also came from behind to beat Tottenham at White Hart Lane earlier in the day.
You can view action and celebration images from the Reds' victory over Stoke by clicking on the photo above.