Following United's win at Stoke City on Sunday, the Reds pulled 15 points clear of Manchester City with just six games to play in the Barclays Premier League.
City have a game extra after competing in the FA Cup on Sunday, but the title is still very much in United’s hands. Indeed, Sir Alex's men now require just seven points from the remaining six fixtures to secure a 20th league title.
Here, we examine the sides Sir Alex’s men will encounter before the season’s end and assess the perils, pitfalls and potential for points along the way...
WEST HAM (A)
Wednesday 17 April, 19:45 BST
Bar the heavy League Cup defeat in 2010, results at Upton Park have generally been positive in recent years. The Reds have been there already this season, although had to rely on a Robin van Persie injury-time strike to salvage a draw. Wayne Rooney didn't play that day but has netted four times on his last two league visits. The Hammers have been steady of late, picking up three wins and two draws from their last 10 games, but they remain in the relegation fight and still require a few more points to be sure of their Premier League status.
ASTON VILLA (H)
Monday 22 April, 20:00 BST
Paul Lambert’s Aston Villa are in an even bigger relegation fight, although their form has picked up in recent weeks and, having claimed an impressive 3-1 win at Stoke in their last away game, they’re unlikely to surrender meekly against the Reds. United overturned a two-goal deficit to win 3-2 at Villa Park in November and will be determined to avoid another slow start. The Villans are still the last league team to keep a clean sheet at Old Trafford (in December 2009) but went down 4-0 in this fixture almost a year ago to the day; a repeat of that scoreline