Sir Alex Ferguson’s men, 15 points ahead of Roberto Mancini's side with eight games left, can take a potentially decisive step towards securing the title with victory at Old Trafford.
A win for the visitors would give them a glimmer of hope of retaining the league crown they claimed ahead of the Reds in such dramatic circumstances last May.
The game also offers United the chance to avenge the 6-1 drubbing by our neighbours in the corresponding fixture last term.
It’s Ferguson vs Mancini, first vs second, red vs blue. Like us, you’re probably already excited - but why not watch our video to further whet your appetite for the 165th meeting of Manchester's mighty Reds and Blues.