The long-serving Reds centre-back played 80 minutes of a lively match against the Spanish outfit, before leaving the field to a standing ovation.
At that time, United were chasing an equaliser after Antonio Valencia had brought the hosts back into the game following two first-half Sevilla goals.
But the visitors, for whom Vitolo and Marko Marin scored before the break, sealed victory in stoppage time through Bryan Rabello as David Moyes’ first Old Trafford match ended in defeat.
Rio’s friends, tennis legend Boris Becker, magician Dynamo and rapper Tinchy Stryder, were among the tens of thousands who came out to honour Ferdinand’s decade of service in the red shirt.
Click the image above to see a gallery of photos from the night.