Manchester United and Real Madrid are two of the biggest names in world football, yet meetings between the sides are relatively rare.
Indeed, Wednesday's last 16, first-leg clash will be only the fifth time the Reds have played at the Bernabeu since first visiting in April 1957.
That night Sir Matt Busby’s men suffered a 3-1 first-leg defeat in the semi-finals of the club’s first ever European Cup foray, eventually bowing out 5-3 on aggregate.
Sir Matt had to wait more than a decade for another crack at Los Blancos and this time, after a 1-0 first-leg win at Old Trafford, his side claimed a famous 3-3 draw to reach the final for the first time.
Sir Alex Ferguson has taken his men to the Bernabeu twice before, though he’s yet to taste victory there. In the 2000 quarter-finals, the Reds claimed a creditable goalless draw but were outclassed in the second leg at Old Trafford.
Three years later, again in the last eight, United went down 3-1 in Spain and, despite a rousing second-leg display, lost 6-5 on aggregate.
Click the image above to see a gallery of photos from United’s previous four trips to the Bernabeu, and let's hope this week brings another positive result there for the Reds.