Teddy Sheringham: 5-0 (H) 28/10/2000
The England international netted three times in 10 minutes to prove he was as sharp as ever at the age of 34. The first strike, a sublime chip, oozed class with strike-partner Andy Cole grabbing the other two goals in a resounding win.
Ruud van Nistelrooy: 6-1 (H) 22/12/2001
This pre-Christmas encounter turned into something of a turkey shoot with another deadly Dutchman helping himself to three of the six goals. The Daily Telegraph's match report described van Nistelrooy as "arguably the most clinical finisher in the world".
Robin van Persie: 3-2 (A) 02/09/2012
The spectacular summer signing may have drilled home a sweet finish but his casual dinked penalty attempt had United heading for defeat. Cue a late double salvo including a header from a corner that snatched all three points on the south coast.
Alan Gowling (1971), George Best (1971) and Mark Hughes (1991) also scored hat-tricks against the Saints with Gowling hitting the net four times.