In between, the Reds will face the other 17 top-flight clubs both home and away, including, of course, the likes of Manchester City, Liverpool, Chelsea, Tottenham and Arsenal.
In our exclusive video we feature action from last season's successful campaign to whet your appetite for what lies ahead this time around. You can relive Robin van Persie's last-minute winner against City, Rafael's sensational strike at Anfield, Javier Hernandez's late goal at Chelsea and plenty of other big moments against the big teams.
Enjoy the video but remember, the dates shown on screen could change. Please keep checking manutd.com/fixtures during the season for confirmation of kick-off times.