The statistics make positive reading for all United fans with 14 of those ties won and only two defeats coming inside 90 minutes.
After Southampton triumphed in the club's first-ever penalty shoot-out in the competition back in 1992, when a young Alan Shearer was on the scoresheet for the Saints, the two actual losses came in consecutive years.
Marcus Gayle's goal earned Wimbledon a 1-0 win at Selhurst Park in 1997, with Peter Schmeichel having a late effort disallowed, while Barnsley stunned the Reds 3-2 in 1998 despite strikes by Teddy Sheringham and Andy Cole.
It took three games to see off QPR in 1989, with youngsters Tony Gill and Deiniol Graham netting at Loftus Road, while the last-ever FA Cup semi-final replay was, of course, one of the greatest games in the club's history as Ryan Giggs saw off Arsenal with an incredible solo winner.
P: 18 W: 14 D: 2 L: 2
* = Southampton won on penalties