The Reds set off on the journey to Ukraine on Tuesday lunchtime after a morning training session at the Aon Training Complex.
Hundreds of excited fans were on hand to greet the team on arrival in Donetsk, before David Moyes and Michael Carrick addressed the media at the pre-match press conference at the Donbass Arena.
United and Shakhtar meet for the first time ever on Wednesday evening and are level on points at the top of Group A after both sides secured victories in their opening games, at home to Bayer Leverkusen and away to Real Sociedad respectively.
It's not just the first team in action in Ukraine, the club's Under-19s, led by Nicky Butt and assisted by Paul Scholes, are playing in the UEFA Youth League against their Shakhtar Donetsk counterparts on Wednesday afternoon.
ManUtd.com journalists Adam Marshall and Gemma Thompson are with the travelling party in Donetsk and will update this article with new images during the trip.