A 19-year-old Ryan scores two late goals in 1993
Matt Le Tissier applauds after Gary Walsh thwarts him in 1994
Denis' penalty takes the 1994/95 title chase to the final day
But Manchester United’s home record against the Saints in the Premier League is almost impeccable: 13 wins and one draw from 14 encounters.
So it’s no surprise that Reds fans have had plenty of moments to savour in this fixture over the years, from late winners to hat-tricks, debut goals and record-breaking strikes.
We’ve picked out nine of our favourite memories from games between United and Southampton at Old Trafford in the Premier League era and you can watch them all in chronological order in our video carousel above.