George Best seals a first-leg win in the 1968 semi v Real Madrid
Barcelona are beaten by a rousing Robbo-inspired comeback in 1984
Lee Sharpe's backheel rescues a draw against Barcelona in 1994
While Manchester United’s home record against Spanish opposition is moderate – eight wins, nine draws and four defeats – there have been numerous games over the years that will live long in the memory.
We’ve come up with a selection of our favourite moments and goals from previous clashes against Real Madrid, Barcelona, Valencia and Deportivo La Coruna, spanning 40 years.
Beginning and ending with historic European Cup semi-final winners, you can watch them all in chronological order above.