It is the first time that the Reds have been drawn away to the Foxes in the competition, however, with the previous three encounters all being played at home.
In 1972, the clubs were paired together in the second round with United earning a 2-1 victory courtesy of goals by Ken Ayres and Brendan McKelvey, to overturn Peter Hearne's opener. Jimmy Nicholl, who went on to become a regular first-teamer at Old Trafford, was in the United line-up. Mike Wardrop had a penalty saved and Graham Capewell was sent off for the Foxes.
Some 15 years later, Leicester turned the tables to win by the same scoreline at Old Trafford. Efforts from Steve Wilkinson and Robert Alleyne left the hosts with a mountain to climb and, although Simon Hutchinson pulled one back, it proved to be in vain.
Mark Robins, who later played first-team football for both clubs, came off the bench for United
Mark Robins played first-team football for both Manchester United and Leicester City, but he was still learning his trade at Old Trafford when the sides met in the FA Youth Cup in 1987.
Robbins is now manager of Huddersfield Town – the Terriers' U18s will be the next opponents for the winners between the Reds and the Foxes in Thursday's Youth Cup tie.